Far-UVC radiation, typically defined as 200-235 nm, has similar or greater anti-microbial efficacy compared to conventional 254-nm germicidal radiation.
In addition, biophysical considerations of the interaction of far-UVC with tissue, as well as multiple short-term safety studies in animal models and humans, suggest that far-UVC exposure may be safe for skin and eye tissue. Nevertheless, the potential for skin cancer after chronic long-term exposure to far-UVC has not been studied.
The research assessed far-UVC induced carcinogenic skin changes and other pathological dermal abnormalities in 96 SKH-1 hairless mice of both sexes that were exposed to average daily dorsal skin doses of 396 mJ/cm2, 126 mJ/cm2 or 56 mJ/cm2 of 222 nm far-UVC radiation for 66 weeks, 5 days per week, 8 hours per day, as well as similarly-treated unexposed controls. No evidence for increased skin cancer, abnormal skin growths, or incidental skin pathology findings was observed in the far-UVC exposed mice.
In addition, there were no significant changes in morbidity or mortality. The findings from this study support the long-term safety of long-term chronic exposure to far-UVC radiation, and therefore its potential suitability as a practical anti-microbial approach to reduce airborne viral and bacterial loads in occupied indoor settings.
In summary, the findings of this study indicate that chronic exposure of SKH-1 hairless mice to far-UVC 222 nm radiation for 66 weeks (15.2 months) at mean daily 8-hour skin doses of up to 400 mJ/cm2 260 did not result in any evidence for induced skin cancer in SKH-1 hairless mice. In addition, we found no evidence of far-UVC related increases in non-cancerous skin lesions, unusual weight loss, or excess mortality.
The SKH-1 hairless mouse is a standard model which as been used to quantify the significant yields of skin cancers and other skin lesions induced by prolonged exposure to UVB radiation and prolonged exposure to conventional germicidal UVC (254 nm) radiation.
This is the first study to estimate skin cancer risk from chronic, long-term far-UVC exposure and the negative results here offer insight into the safety of human skin after prolonged 222 nm exposure. The negative findings reported here are pertinent to the potential use of far-UVC technology to control airborne microbe transmission in occupied indoor spaces.
Know more: https://www.biorxiv.org/content/10.1101/2022.03.16.484636v1
My Lumens Artemis Far UVC Disinfection Devices equipped with Care222 module(filtered far uvc 222nm technology) developed by Ushio, Japan.
Care222 is a new disinfecting light source that, even though not harmful to the skin or eyes of humans or animals, deactivates bacteria and viruses in the same manner as conventional ultraviolet sanitizers.
Care222 uses an excimer lamp (a mercury-free UV excimer light source produced by Ushio especially for outputting monochromatic ultraviolet with a primary wavelength of 222 nm) in combination with a special optical bandpass filter (200 to 230 nm) which passes only ultraviolet wavelengths that have no harmful effect on people.
Only 222 nm, which is filtered by a special optical bandpass filter for the rest of the harmful wavelengths, is safe for humans.
Ushio holds exclusive rights to utilization of the key technology, which was patented by Columbia University (New York, NY) in 2012.
Know more information about Care222 technology: www.care222.com