By Published On: April 25, 2022
Home » Chronic irradiation with 222-nm UVC light induces neither DNA damage nor epidermal lesions in mouse skin, even at high doses

Surgical site infections (SSIs) represent an important clinical problem associated with increased levels of surgical morbidity and mortality. UVC irradiation during surgery has been considered to represent a possible strategy to prevent the development of SSI. 254-nm UVC induces marked levels of DNA damage by generating cyclobutyl pyrimidine dimers (CPD) in microorganisms. However, this effect is elicited not only in microorganisms, but also in human cells, and chronic exposure to 254-nm UVC has been established to represent a human health hazard. In contrast, despite short wavelength-UVC light, especially 222-nm UVC, having been demonstrated to elicit a bactericidal effect, single irradiation with a high dose of 222-nm UVC energy has been reported to not induce mutagenic or cytotoxic DNA lesions in mammalian cells. These results indicated that 222-nm UVC light emitted from the lamp apparatus (or device), which was designed to attenuate harmful light present in wavelengths of more than 230 nm, represents a promising tool for the reduction of SSI incidence in patients and hospital staff.

In the present study, irradiation with 254-nm UVC light for 5 consecutive days induced sunburn and desquamation in the epidermis of mice. Despite these effects being attenuated after a further 2 days of treatment, affected skin lesions were exacerbated following re-irradiation with 254-nm UVC for a further 3 consecutive days. In contrast, lesions were not observed in the dorsal skin of mice consecutively irradiated with 222-nm UVC, or mice that were not subjected to irradiation, during observation.

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My Lumens Artemis Far UVC Disinfection Devices equipped with Care222 module(filtered far uvc 222nm technology) developed by Ushio, Japan.

Care222 is a new disinfecting light source that, even though not harmful to the skin or eyes of humans or animals, deactivates bacteria and viruses in the same manner as conventional ultraviolet sanitizers.

Does not cause sunburn, skin cancer or cataracts

Ultraviolet rays with a wavelength of 222 nm are absorbed by the cornea of ​​the stratum corneum of dead cells, so they do not cause damage such as sunburn, skin cancer, and cataracts.

Virus suppression / sterilization

Ultraviolet rays with a wavelength of 222 nm destroy the DNA / RNA structure of viruses and cells, and suppress and sterilize them.

A key advantage of the UV-based approach is that UV light is likely to be effective against all airborne microorganisms, in marked contrast to vaccination methods. For example, while the inactivation efficiency of UV light will almost certainly vary as different strains of influenza virus emerge, they are unlikely to be significant. Similarly, as multidrug-resistant variants of bacteria emerge, their UV inactivation capacity is unlikely to vary greatly.

The use of Care222 in public places is a safe and effective way to limit the spread and transmission of air-mediated microbial diseases, such as schools, hospitals, stadiums, sports grounds and offices, and this approach may help to limit seasonal infections, the spread of tuberculosis and major epidemics.

Click here to know more about Ushio’s Care222 technology: www.care222.com

Continuously disinfecting in occupied space but not harmful to skin and eyes of people, which could be used in dental offices, medical rooms, high-end offices, elevators, hospitals, class rooms, etc.

Care for you, Safe for you, and Protect you!

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